The Safety Policies for the Organism from Genome Editing Technology in US and Europe and the Implication for China
He Xiaodan1, Chen Qiqi2, Zhan Jintao2, 3
1.School of Environment and Natural Resources,Renming University of China,Beijing 100872,China; 2.College of Economics and Management,Nanjing Agricultural University,Nanjing 210095,China; 3.China Center for Food Security Research,Nanjing Agricultural University,Nanjing 210095,China
Abstract：Genome editing technology(GET)provides a revolutionary genetic manipulation tool for crop genetic improvement.However,the policies for GET safety regulation remain unclear across the world.Based on a comprehensive review of the development of genomics editing techniques,this paper analyzes the strategies and core ideas of the regulation for the GET in Europe and the United States deeply,identifying the similarities and differences between GET and GMO safety management policies.Based on the analysis,the paper finally provides suggestions to GET safety management policy formulation for policy making in China.
何晓丹, 陈琦琦, 展进涛. 欧美等国基因组编辑生物安全管理政策及对中国的启示[J]. 中国科技论坛, 2018(8): 183-188.
He Xiaodan, Chen Qiqi, Zhan Jintao. The Safety Policies for the Organism from Genome Editing Technology in US and Europe and the Implication for China. , 2018(8): 183-188.
[1]肖安,胡莹莹,王唯晔.人工锌指核酸酶介导的基因组定点修饰技术[J].遗传,2011,33(7):665-683. [2]JINEK M,CHYLINSKI K,FONFARA I,HAUER M,DOUDNA J,CHARPENTIER E.A programmable Dual-Rna-Guided Dna endonuclease in Adaptive Bacterial Immunity[J].Science,2012,337(6096):816-821. [3]沈平,章秋艳,杨立桃,张丽,李文龙,梁晋刚,李夏莹,王颢潜,沈晓玲,宋贵文.基因组编辑技术及其安全管理[J].中国农业科学,2017,50(8):1361-1369. [4]DOUDNAJ,CHARPENTIER E.Genome editing:The new frontier of genome engineering with CRISPR-Cas9[J].Science.2014,346(6213):1258096. [5]TRIBLEW,OLIVOS-CISNEROS L,MCKENZIE S K,SARAGOSTI J,CHANG N,MATTHEWS B J,OXLEY P R,KRONAUER D.Orco mutagenesis causes loss of antennal lobe glomeruli and impaired social behavior in Ants[J].Cell,2017,170(4):727-735. [6]LEDFORD H.US rethinks crop regulation[J].Nature,2016,532:158-159. [7]JONES D.Regulatory uncertainty over genome editing.[J].Nature plants,2015,1:14011. [8]WANG J,XU Z,LIU S,ZHANG R,DING S,XIE X,LONG L,CHEN X,ZHUANG H,LU F.Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication[J].World J gastroenterol,2015,21(32):9554-9565. [9]DING S,YANG Z,WANG J,ZHANG X,CHEN X,LUF F.Integrative analysis of aberrant wnt signaling in hepatitis B Virus-Related hepatocellular carcinoma[J].World J gastroenterol,2015,21(20):6317-6328. [10]SHAN W,ZHANG Y,CHEN L,ZHAN K,GAO X.Creation of fragrant rice by targeted knockout of the Osbadh2 Gene Using TALEN technology.[J].Plant biotechnology journal,2015,13(6):791-800. [11]沈延,肖安,黄鹏,王唯晔,朱作言,张博.类转录激活因子效应物核酸酶(TALEN)介导的基因组定点修饰技术[J].遗传,2013,35(4):295-309. [12]GOTTESFELD J,NEELY L,TRAUGER J,BAIRd E,DERVAN P.Regulation of gene expression by small molecules[J].Nature,1997,387,202-205. [13]SPRINK T,METJE J,SCHIEMANN J,HARTUNG Y.Plant genome editing in The European Union-To Be or Not To Be-A GMO[J].Plant biotechnology reports,2016,10(6):345-351. [14]DAVISON J,AMMANN K.New GMO regulations for old:determining a new future for EU crop biotechnology[J].Gm crops & Food-Biotechnology in agriculture and the food chain,2017,8(1):13-34. [15]ISHII T,ARAKI M.A future scenario of the global regulatory landscape regarding genome-edited crops[J].Gm crops & food-biotechnology in agriculture and the food chain,2017,8(1):44-56. [16]SMYTH J.Canadian regulatory perspectives on genome engineered crops[J].Gm crops & food-biotechnology in agriculture and the food chain,2017,8(1):35-43.
2018, 
