Abstract：This paper built a specific connection network based on transaction projects of enterprises' technology supply and demand in Wuhan bio-medicine industry.Structure embeddedness represents the overall function of network and the information control edge.We took degree centrality,centrality and structural holes as indicators to study on the effects of network structure to enterprise innovation performance.The results show:degree centrality and betweenness centrality have positive impact on enterprise's innovation performance;closeness centrality generates negative impact;while structure hole doesn't have relationship with innovation performance.Professional platforms for technology innovation which play significant role in connecting enterprises or professional institutions should be developed;the laboratory economy which is dominant by the core-firm should be established;supports to some dominant enterprises should be cut down
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